A decade after Serpent of Moses, Jack is married to Espy and back teaching at Evanston University. They have two sons, one of whom has cystic fibrosis. Despite this challenge, life is comfortable. But that all changes when the CIA, while combing through the papers of the late Gordon Reese, uncovers the secret of Elisha's bones. Jack's world is then turned upside down by an urgent call from his old friend Duckey, who's been alerted to the CIA's probing by one of his former contacts. Jack and his family escape from their home just ahead of the CIA, and he decides to do what he should have done long ago: recover the bones and destroy them. Except the bones aren't where he left them.