It's fall and everyone in Room 26 is excited that Halloween is coming, but this year something even more fur-raising is going on---Mrs. Brisbane is missing! She's stopped coming to school and Humphrey has no idea where she is. Luckily, Humphrey has just learned about an smart detective named Sherlock Holmes, who is great at collecting clues and following leads---just what Humphrey will have to do to solve the case!